Ontology highlight
ABSTRACT:
SUBMITTER: Zhou B
PROVIDER: S-EPMC5327789 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhou Bin B Wu Yan Y Dalal Seema S Merino Emilio F EF Liu Qun-Fang QF Xu Cheng-Hui CH Yuan Tao T Ding Jian J Kingston David G I DG Cassera Maria B MB Yue Jian-Min JM
Journal of natural products 20161220 1
Inspired by the discovery of the antimalarial drug artemisinin from a traditional Chinese medicine (TCM), a natural product library of 44 lindenane-type sesquiterpenoids was assessed for activities against the Dd2 chloroquine-resistant strain of the malaria parasite Plasmodium falciparum. These compounds were mainly isolated from plants of the Chloranthus genus, many species of which are named "Sikuaiwa" in TCM and have long been used to treat malaria. The compounds consisted of 41 sesquiterpeno ...[more]