A systematic review of occupational exposure to coal dust and the risk of interstitial lung diseases.
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ABSTRACT:
SUBMITTER: Beer C
PROVIDER: S-EPMC5328367 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
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A systematic review of occupational exposure to coal dust and the risk of interstitial lung diseases.
Beer Christiane C Kolstad Henrik A HA Søndergaard Klaus K Bendstrup Elisabeth E Heederik Dick D Olsen Karen E KE Omland Øyvind Ø Petsonk Edward E Sigsgaard Torben T Sherson David L DL Schlünssen Vivi V
European clinical respiratory journal 20170103 1
<b>Objective</b>: Exposure to coal dust can cause interstitial lung disease (ILD), but whether this is due to pure coal or to the contents of quartz in coal is less clear. Here, we systematically reviewed the relation between 'pure coal' and ILD. <b>Methods</b>: In a systematic review based on PRISMA criteria 2945 articles were identified. Strict eligibility criteria, which evaluated the 'pure coal effect', led to the inclusion of only nine studies. <b>Results</b>: Among these nine studies six s ...[more]
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Project description:ObjectiveTo examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.MethodsIn this population-based case-control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968-2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968-2016 and 1989-2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).ResultsFor births 1968-2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] 1.04-1.63) and germ cell tumors (OR = 1.82, 95% CI 1.05-3.27), while maternal pregnancy exposure was associated with astrocytoma (OR = 1.89, 95% CI 1.00-3.57). For births 1989-2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR = 0.58, 95% CI 0.33-1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR = 2.16, 95% CI 1.09-4.29).ConclusionsThis study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes.
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