Unknown

Dataset Information

0

Programmed cell death as a defence against infection.

ABSTRACT: Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens. Finally, we describe how the resulting cell corpses - apoptotic bodies, pore-induced intracellular traps (PITs) and neutrophil extracellular traps (NETs) - promote the clearance of infection.

SUBMITTER: Jorgensen I 

PROVIDER: S-EPMC5328506 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Programmed cell death as a defence against infection.

Jorgensen Ine I   Rayamajhi Manira M   Miao Edward A EA  

Nature reviews. Immunology 20170131 3

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that  ...[more]

Similar Datasets

Transcriptomics The cyanobacterium, Nostoc punctiforme can protect against programmed cell death and induce defence genes in Arabidopsis thaliana.
2020-12-10 | GSE155980 | GEO
Unknown Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).
| S-EPMC3773803 | biostudies-other
Unknown The Fusarium mycotoxin deoxynivalenol elicits hydrogen peroxide production, programmed cell death and defence responses in wheat.
| S-EPMC6640518 | biostudies-other
Unknown Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro.
| S-EPMC7177768 | biostudies-literature
Unknown Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection.
| S-EPMC4773807 | biostudies-other
Unknown Programmed cell death in aging.
| S-EPMC4480161 | biostudies-literature
Unknown Harpin and hydrogen peroxide both initiate programmed cell death but have differential effects on defence gene expression in Arabidopsis suspension cultures.
| S-EPMC1219116 | biostudies-other
Unknown Programmed Cell Death after Intracerebral Hemorrhage.
| S-EPMC6251052 | biostudies-literature
Unknown Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.
| S-EPMC3823652 | biostudies-literature
Unknown New Combination Strategies Using Programmed Cell Death 1/Programmed Cell Death Ligand 1 Checkpoint Inhibitors as a Backbone.
| S-EPMC5844278 | biostudies-literature