Ontology highlight
ABSTRACT:
SUBMITTER: Mitra RN
PROVIDER: S-EPMC5328608 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Mitra Rajendra Narayan RN Nichols Chance A CA Guo Junjing J Makkia Rasha R Cooper Mark J MJ Naash Muna I MI Han Zongchao Z
Journal of controlled release : official journal of the Controlled Release Society 20160611
We recently reported that the Ins2(Akita) mouse is a good model for late-onset diabetic retinopathy. Here, we investigated the effect of miR200-b, a potential anti-angiogenic factor, on VEGF receptor 2 (VEGFR-2) expression and to determine the underlying angiogenic response in mouse endothelial cells, and in retinas from aged Ins2(Akita) mice. MiR200-b and its native flanking sequences were amplified and cloned into a pCAG-eGFP vector directed by the ubiquitous CAG promoter (namely pCAG-miR200-b ...[more]