Dataset Information

Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case-control study.

ABSTRACT: BACKGROUND:The aim of this case-control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population. SUBJECTS AND METHODS:A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype. RESULTS:In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09-0.79), whereas the G allele of the SNP rs2428707 was associated with an increased risk of suicide attempt (P=0.01, odds ratio =3.68, 95% confidence interval: 1.24-10.90). No significant association was observed between the other polymorphisms studied (rs547536, rs2192372, rs6318) or haplotypes with suicide attempts. CONCLUSION:These findings suggest a possible risk factor of the HTR2C gene in the pathology of suicidal behavior in Mexican population. More studies are necessary to confirm this association.

SUBMITTER: Molina-Guzman G

PROVIDER: S-EPMC5328611 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Gender differences in the association between <i>HTR2C</i> gene variants and suicidal behavior in a Mexican population: a case-control study.

Molina-Guzman Gabriel G González-Castro Thelma Beatriz TB Hernández Díaz Yazmín Y Tovilla-Zárate Carlos Alfonso CA Juárez-Rojop Isela E IE Guzmán-Priego Crystell Guadalupe CG Genis Alma A Pool García Sherezada S López-Narvaez María Lilia ML Rodriguez-Perez José Manuel JM

Neuropsychiatric disease and treatment 20170222

<h4>Background</h4>The aim of this case-control study was to explore the association by gender between the <i>HTR2C</i> gene variants and suicidal behavior in a Mexican population.<h4>Subjects and methods</h4>A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype.<h4>Results</h4>In the female group, w ...[more]

PMID: 28260903

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Project description:ImportanceAlthough almost equal numbers of male and female medical students enter into ophthalmology residency programs, whether they have similar surgical experiences during training is unclear.ObjectiveTo determine differences for cataract surgery and total procedural volume between male and female residents during ophthalmology residency.Design, setting, participantsThis retrospective, longitudinal analysis of resident case logs from 24 US ophthalmology residency programs spanned July 2005 to June 2017. A total of 1271 residents were included. Data were analyzed from August 12, 2017, through April 4, 2018.Main outcomes and measuresVariables analyzed included mean volumes of cataract surgery and total procedures, resident gender, and maternity or paternity leave status.ResultsAmong the 1271 residents included in the analysis (815 men [64.1%]), being female was associated with performing fewer cataract operations and total procedures. Male residents performed a mean (SD) of 176.7 (66.2) cataract operations, and female residents performed a mean (SD) of 161.7 (56.2) (mean difference, -15.0 [95% CI, -22.2 to -7.8]; P < .001); men performed a mean (SD) of 509.4 (208.6) total procedures and women performed a mean (SD) of 451.3 (158.8) (mean difference, -58.1 [95% CI, -80.2 to -36.0]; P < .001). Eighty-five of 815 male residents (10.4%) and 71 of 456 female residents (15.6%) took parental leave. Male residents who took paternity leave performed a mean of 27.5 (95% CI, 13.3 to 41.6; P < .001) more cataract operations compared with men who did not take leave, but female residents who took maternity leave performed similar numbers of operations as women who did not take leave (mean difference, -2.0 [95% CI, -18.0 to 14.0]; P = .81). From 2005 to 2017, each additional year was associated with a 5.5 (95% CI, 4.4 to 6.7; P < .001) increase in cataract volume and 24.4 (95% CI, 20.9 to 27.8; P < .001) increase in total procedural volume. This increase was not different between genders for cataract procedure volume (β = -1.6 [95% CI, -3.7 to 0.4]; P = .11) but was different for total procedural volume such that the increase in total procedural volume over time for men was greater than that for women (β = -8.0 [95% CI, -14.0 to -2.1]; P = .008).Conclusions and relevanceFemale residents performed 7.8 to 22.2 fewer cataract operations and 36.0 to 80.2 fewer total procedures compared with their male counterparts from 2005 to 2017, a finding that warrants further exploration to ensure that residents have equivalent surgical training experiences during residency regardless of gender. However, this study included a limited number of programs (24 of 119 [20.2%]). Future research including all ophthalmology residency programs may minimize the selection bias issues present in this study.

Dataset Information

Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case-control study.

Publications

Gender differences in the association between <i>HTR2C</i> gene variants and suicidal behavior in a Mexican population: a case-control study.

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