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A versatile platform for surface modification of microfluidic droplets.

ABSTRACT: To advance emulsion droplet technology, we synthesize functional derivatives of Pluronic F127 that can simultaneously act as surfactants and as reactive sites for droplet surface decoration. The amine-, carboxyl-, N-hydroxysuccinimide ester-, maleimide- and biotin-terminated Pluronic F127 allows ligand immobilization on single-emulsion or double-emulsion droplets via electrostatic adsorption, covalent conjugation or site-specific avidin-biotin interaction.

SUBMITTER: Li M

PROVIDER: S-EPMC5328679 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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A versatile platform for surface modification of microfluidic droplets.

Li Mingqiang M Jiang Weiqian W Chen Zaozao Z Suryaprakash Smruthi S Lv Shixian S Tang Zhaohui Z Chen Xuesi X Leong Kam W KW

Lab on a chip 20170201 4

To advance emulsion droplet technology, we synthesize functional derivatives of Pluronic F127 that can simultaneously act as surfactants and as reactive sites for droplet surface decoration. The amine-, carboxyl-, N-hydroxysuccinimide ester-, maleimide- and biotin-terminated Pluronic F127 allows ligand immobilization on single-emulsion or double-emulsion droplets via electrostatic adsorption, covalent conjugation or site-specific avidin-biotin interaction. ...[more]

PMID: 28154857

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