Insights into Dynamic Polymicrobial Synergy Revealed by Time-Coursed RNA-Seq.

ABSTRACT: Many bacterial infections involve polymicrobial communities in which constituent organisms are synergistically pathogenic. Periodontitis, a commonly occurring chronic inflammatory disorder, is induced by multispecies bacterial communities. The periodontal keystone pathogen Porphyromonas gingivalis and the accessory pathogen Streptococcus gordonii exhibit polymicrobial synergy in animal models of disease. Mechanisms of co-adhesion and community formation by P. gingivalis and S. gordonii are well-established; however, little is known regarding the basis for increased pathogenicity. In this study we used time-coursed RNA-Seq to comprehensively and quantitatively examine the dynamic transcriptional landscape of P. gingivalis in a model consortium with S. g

SUBMITTER: Hendrickson EL 

PROVIDER: S-EPMC5329018 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature