Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps.
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ABSTRACT:
SUBMITTER: Behnen M
PROVIDER: S-EPMC5329032 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps.
Behnen Martina M Möller Sonja S Brozek Antonia A Klinger Matthias M Laskay Tamás T
Frontiers in immunology 20170228
The inflammatory microenvironment is commonly characterized by extracellular acidosis (pH < 7.35). Sensitivity to pH, CO<sub>2</sub> or bicarbonate concentrations allows neutrophils to react to changes in their environment and to detect inflamed areas in the tissue. One important antimicrobial effector mechanism is the production of neutrophil extracellular traps (NETs), which are released during a programmed reactive oxygen species (ROS)-dependent cell death, the so-called NETosis. Although sev ...[more]
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