Ontology highlight
ABSTRACT:
SUBMITTER: Zhong C
PROVIDER: S-EPMC5329619 | biostudies-literature | 2017 Jan-Feb
REPOSITORIES: biostudies-literature
Zhong Chongbo C Akmentin Wendy W Du Chuang C Role Lorna W LW Talmage David A DA
eNeuro 20170101 1
Altered neuregulin 1 (Nrg1)/ErbB signaling and glutamatergic hypofunction have been implicated in the pathophysiology of schizophrenia. Here, we employed gene chimeric ventral hippocampus (vHipp)-nucleus accumbens (nAcc) coculture from mouse, electrophysiology, immunocytochemistry, FM1-43 vesicle fusion, and electron microscopy techniques to examine the pre- and postsynaptic mechanisms of genetic deficits in Nrg1/ErbB signaling-induced glutamatergic dysfunctions. Reduced presynaptic type III Nrg ...[more]