Ontology highlight
ABSTRACT:
SUBMITTER: Vahsen N
PROVIDER: S-EPMC533047 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Vahsen Nicola N Candé Céline C Brière Jean-Jacques JJ Bénit Paule P Joza Nicholas N Larochette Nathanael N Mastroberardino Pier Giorgio PG Pequignot Marie O MO Casares Noelia N Lazar Vladimir V Feraud Olivier O Debili Najet N Wissing Silke S Engelhardt Silvia S Madeo Frank F Piacentini Mauro M Penninger Josef M JM Schägger Hermann H Rustin Pierre P Kroemer Guido G
The EMBO journal 20041104 23
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, after apoptosis induction, translocates to the nucleus where it participates in apoptotic chromatinolysis. Here, we show that human or mouse cells lacking AIF as a result of homologous recombination or small interfering RNA exhibit high lactate production and enhanced dependency on glycolytic ATP generation, due to severe reduction of respiratory chain complex I activity. Although AIF itself is not a part of complex I, AIF-def ...[more]