Ontology highlight
ABSTRACT:
SUBMITTER: Monzon AM
PROVIDER: S-EPMC5330503 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
PLoS computational biology 20170213 2
Protein motions are a key feature to understand biological function. Recently, a large-scale analysis of protein conformational diversity showed a positively skewed distribution with a peak at 0.5 Å C-alpha root-mean-square-deviation (RMSD). To understand this distribution in terms of structure-function relationships, we studied a well curated and large dataset of ~5,000 proteins with experimentally determined conformational diversity. We searched for global behaviour patterns studying how struc ...[more]