Ontology highlight
ABSTRACT:
SUBMITTER: Watson J
PROVIDER: S-EPMC5330681 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Watson James J Taylor Walter Rj WR Menard Didier D Kheng Sim S White Nicholas J NJ
eLife 20170204
Primaquine is the only drug available to prevent relapse in vivax malaria. The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd). As testing for G6PDd is often unavailable, this limits the use of primaquine for radical cure. A compartmental model of the dynamics of red blood cell production and destruction was designed to characterise primaquine-induced haemolysis using a holis ...[more]