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ABSTRACT:
SUBMITTER: Murugesapillai D
PROVIDER: S-EPMC5331113 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Murugesapillai Divakaran D McCauley Micah J MJ Maher L James LJ Williams Mark C MC
Biophysical reviews 20161115 1
Protein-DNA interactions can be characterized and quantified using single molecule methods such as optical tweezers, magnetic tweezers, atomic force microscopy, and fluorescence imaging. In this review, we discuss studies that characterize the binding of high-mobility group B (HMGB) architectural proteins to single DNA molecules. We show how these studies are able to extract quantitative information regarding equilibrium binding as well as non-equilibrium binding kinetics. HMGB proteins play cri ...[more]