Ontology highlight
ABSTRACT:
SUBMITTER: Rosselin M
PROVIDER: S-EPMC5331265 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Rosselin Manon M Santo-Domingo Jaime J Bermont Flavien F Giacomello Marta M Demaurex Nicolas N
EMBO reports 20170207 3
Mitochondrial flashes mediated by optic atrophy 1 (OPA1) fusion protein are bioenergetic responses to stochastic drops in mitochondrial membrane potential (Δψ<sub>m</sub>) whose origin is unclear. Using structurally distinct genetically encoded pH-sensitive probes, we confirm that flashes are matrix alkalinization transients, thereby establishing the pH nature of these events, which we renamed "mitopHlashes". Probes located in cristae or intermembrane space as verified by electron microscopy do ...[more]