Ontology highlight
ABSTRACT:
SUBMITTER: Mijalkovic J
PROVIDER: S-EPMC5331336 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Mijalkovic Jona J Prevo Bram B Oswald Felix F Mangeol Pierre P Peterman Erwin J G EJ
Nature communications 20170223
Cytoplasmic dyneins drive microtubule-based, minus-end directed transport in eukaryotic cells. Whereas cytoplasmic dynein 1 has been widely studied, IFT dynein has received far less attention. Here, we use fluorescence microscopy of labelled motors in living Caenorhabditis elegans to investigate IFT-dynein motility at the ensemble and single-molecule level. We find that while the kinesin composition of motor ensembles varies along the track, the amount of dynein remains relatively constant. Rema ...[more]