Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki K
PROVIDER: S-EPMC5331785 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Suzuki Keiichiro K Tsunekawa Yuji Y Hernandez-Benitez Reyna R Wu Jun J Zhu Jie J Kim Euiseok J EJ Hatanaka Fumiyuki F Yamamoto Mako M Araoka Toshikazu T Li Zhe Z Kurita Masakazu M Hishida Tomoaki T Li Mo M Aizawa Emi E Guo Shicheng S Chen Song S Goebl April A Soligalla Rupa Devi RD Qu Jing J Jiang Tingshuai T Fu Xin X Jafari Maryam M Esteban Concepcion Rodriguez CR Berggren W Travis WT Lajara Jeronimo J Nuñez-Delicado Estrella E Guillen Pedro P Campistol Josep M JM Matsuzaki Fumio F Liu Guang-Hui GH Magistretti Pierre P Zhang Kun K Callaway Edward M EM Zhang Kang K Belmonte Juan Carlos Izpisua JC
Nature 20161116 7631
Targeted genome editing via engineered nucleases is an exciting area of biomedical research and holds potential for clinical applications. Despite rapid advances in the field, in vivo targeted transgene integration is still infeasible because current tools are inefficient, especially for non-dividing cells, which compose most adult tissues. This poses a barrier for uncovering fundamental biological principles and developing treatments for a broad range of genetic disorders. Based on clustered re ...[more]