Ontology highlight
ABSTRACT:
SUBMITTER: Bai J
PROVIDER: S-EPMC5332125 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bai Jing J Lu Yuanyuan Y Xu Ya-ming YM Zhang Wei W Chen Ming M Lin Min M Gunatilaka A A Leslie AA Xu Yuquan Y Molnár István I
Organic letters 20160302 6
Two disparate polyketide families, the benzenediol lactones and the azaphilones, are produced by fungi using iterative polyketide synthase (iPKS) enzymes consisting of collaborating partner subunits. Exploitation of this common biosynthetic logic using iPKS subunit shuffling allowed the diversity-oriented combinatorial biosynthesis of unprecedented polyketide scaffolds new to nature, bearing structural motifs from both of these orthogonal natural product families. Starter unit acyltransferase do ...[more]