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Association of blood heavy metals with developmental delays and health status in children.

ABSTRACT: The aim of this study was to evaluate the association of blood lead, mercury, and cadmium concentrations with developmental delays and to explore the association of these concentrations with the health status of children. This study recruited 89 children with developmental delays and 89 age- and sex-matched children with typical development. Their health status was evaluated using the Pediatric Quality of Life (PedsQL) Inventory for health-related quality of life (HRQOL) and the Pediatric Outcomes Data Collection Instrument for function. Family function was also evaluated. Blood lead, mercury, and cadmium concentrations were measured using inductively coupled mass spectrometry. The children with developmental delays had a considerably poorer HRQOL, lower functional performance and family function, and a higher blood lead concentration than those with typical development. The blood lead concentration had a significantly positive association with developmental delays [odds ratio (OR)?=?1.54, p?1.0??g/L vs. <0.6??g/L, p?

SUBMITTER: Hsueh YM

PROVIDER: S-EPMC5333623 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Association of blood heavy metals with developmental delays and health status in children.

Hsueh Yu-Mei YM Lee Chih-Ying CY Chien Ssu-Ning SN Chen Wei-Jen WJ Shiue Horng-Sheng HS Huang Shiau-Rung SR Lin Ming-I MI Mu Shu-Chi SC Hsieh Ru-Lan RL

Scientific reports 20170302

The aim of this study was to evaluate the association of blood lead, mercury, and cadmium concentrations with developmental delays and to explore the association of these concentrations with the health status of children. This study recruited 89 children with developmental delays and 89 age- and sex-matched children with typical development. Their health status was evaluated using the Pediatric Quality of Life (PedsQL) Inventory for health-related quality of life (HRQOL) and the Pediatric Outcom ...[more]

PMID: 28252669

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Project description:This study investigated the effects of a short-term family-centered workshop for children with developmental delays.This study was conducted in a rehabilitation outpatient clinic of a teaching hospital. We recruited 30 children with developmental delays and their parents as the study group and 57 age- and sex-matched children with typical development and their parents as the control group. The workshop was conducted for the children with developmental delays and their parents in the form of one 2-hour session per week for 6 weeks by health and education professionals by using a family-centered multidisciplinary approach. The Mandarin-Chinese Communicative Developmental Inventory and Peabody Developmental Motor Scales-Second Edition were used to assess the communication and motor skills of the children with developmental delays. The parent form of the Pediatric Outcomes Data Collection Instrument, Child Health Questionnaire, Pediatric Quality of Life (PedsQL) Inventory, and PedsQL Family Impact Module were administered to the parents of both groups.On study commencement, no significant differences were noted in functional performance and family impact between the children with developmental delays and those without delays. The children with developmental delays had lower health and health-related quality of life (HRQOL) scores than the children with typical development. Following the workshop, the study group exhibited significant improvements in physical health (94.2 vs 80.2, effect size: 1.00, P?=?.026), global function (94.8 vs 78.7, effect size: 0.88, P?=?.006), impact of the child's health on parental HRQOL (85.0 vs 70.4, effect size: 0.81, P?=?.043), and parental HRQOL (81.3 vs 65.0, effect size: 0.81, P?=?.015). No significant differences were recorded in function, health, HRQOL, or family impact between the children with developmental delays and those with typical development after 6 weeks.The multidisciplinary short-term family-centered workshop for children with developmental delays improved the children's physical health and global functional skills, and it reduced the impact of the child's health on parental HRQOL while also improving parental HRQOL.

Dataset Information

Association of blood heavy metals with developmental delays and health status in children.

Publications

Association of blood heavy metals with developmental delays and health status in children.

Similar Datasets

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