Dataset Information

Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.

ABSTRACT:

Background

Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma.

Methods

We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects.

Results

First approach: 50 SNPs were selected based on an overall interaction effect at p<10-4. The most pronounced interaction effect was observed for rs9969775 on chromosome 9 (discovery meta-analysis: ORint = 0.50, p = 7.63*10-5, replication: ORint = 0.65, p = 0.02). Second approach: 35 SNPs were selected based on the overall genetic effect in exposed subjects (p <10-4). The most pronounced genetic effect was observed for rs5011804 on chromosome 12 (discovery meta-analysis ORint = 1.50, p = 1.21*10-4; replication: ORint = 1.40, p = 0.03).

Conclusions

Using two genome-wide interaction approaches, we identified novel polymorphisms in non-annotated intergenic regions on chromosomes 9 and 12, that showed suggestive evidence for interaction with active tobacco smoking in the onset of adult asthma.

SUBMITTER: Vonk JM

PROVIDER: S-EPMC5333809 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.

Vonk J M JM Scholtens S S Postma D S DS Moffatt M F MF Jarvis D D Ramasamy A A Wjst M M Omenaas E R ER Bouzigon E E Demenais F F Nadif R R Siroux V V Polonikov A V AV Solodilova M M Ivanov V P VP Curjuric I I Imboden M M Kumar A A Probst-Hensch N N Ogorodova L M LM Puzyrev V P VP Bragina E Yu EY Freidin M B MB Nolte I M IM Farrall A M AM Cookson W O C M WO Strachan D P DP Koppelman G H GH Boezen H M HM

PloS one 20170302 3

<h4>Background</h4>Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma.<h4>Methods</h4>We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the gene ...[more]

PMID: 28253294

Similar Datasets

Project description:INTRODUCTION:Tobacco smoking is the largest preventable cause of global mortality, with its prevalence increasing in Sub-Saharan Africa, particularly among adolescents. We sought to determine the factors associated with tobacco smoking among Nigerian school adolescents and investigate the interaction between school location and socioeconomic status (SES). METHODS:Using a cross-sectional study design, 4332 eighth to tenth grade students in rural and urban secondary schools in Enugu State, Nigeria, were selected by stratified two-stage cluster sampling. We collected data using a modified Global Youth Tobacco Survey (GYTS) Core Questionnaire. Outcome measures were current smoking of cigarettes and other smoked tobacco. Multilevel mixed effects logistic regression models were used to determine factors associated with current tobacco smoking and were considered statistically significant at p<0.05. RESULTS:Prevalences of current smoking of cigarettes and other smoked tobacco were 13.3% (95% CI: 11.3-15.7) and 5.8% (95% CI: 4.6-7.2), respectively. Possession of higher weekly allowance, exposure to secondhand smoke or tobacco advertisements, having smoking parents, friends or classmates who smoke, and sale of cigarettes near school, were positively associated with current smoking of tobacco. Female sex, having both parents employed and being exposed to tobacco teaching in school were negatively associated with current cigarette smoking while increasing age and high father's SES were negatively associated with current smoking of other tobacco products. There was an interaction between school location and father's SES in the association with cigarette smoking. The higher odds of smoking in rural versus urban schools were much higher for students with fathers of high SES compared to low SES. In rural schools, high SES was associated with higher odds of smoking, but in urban schools low SES was associated with higher odds of smoking. CONCLUSIONS Environmental factors are associated with adolescent tobacco smoking. Tobacco control programs should use targeted strategies that vary depending on the local context.

Dataset Information

Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.

Background

Methods

Results

Conclusions

Publications

Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium.

Similar Datasets

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