Dataset Information

Colon cancer modulation by a diabetic environment: A single institutional experience.

ABSTRACT:

Background

Multiple observational studies suggest an increased risk of colon cancer in patients with diabetes mellitus (DM). This can theoretically be the result of an influence of the diabetic environment on carcinogenesis or the tumor biologic behavior.

Aim

To gain insight into the influence of a diabetic environment on colon cancer characteristics and outcomes.

Material and methods

Retrospective analysis of clinical records in an academic tertiary care hospital with detailed analysis of 81 diabetic patients diagnosed of colon cancer matched with 79 non-diabetic colon cancer patients. The impact of streptozotocin-induced diabetes on the growth of colon cancer xenografts was studied in mice.

Results

The incidence of DM in 1,137 patients with colorectal cancer was 16%. The diabetic colon cancer cases and non-diabetic colon cancer controls were well matched for demographic and clinical variables. The ECOG Scale Performance Status was higher (worse) in diabetics (ECOG ?1, 29.1% of controls vs 46.9% of diabetics, p = 0.02), but no significant differences were observed in tumor grade, adjuvant therapy, tumor site, lymphovascular invasion, stage, recurrence, death or cancer-related death. Moreover, no differences in tumor variables were observed between patients treated or not with metformin. In the xenograft model, tumor growth and histopathological characteristics did not differ between diabetic and nondiabetic animals.

Conclusion

Our findings point towards a mild or negligible effect of the diabetes environment on colon cancer behavior, once cancer has already developed.

SUBMITTER: Prieto I

PROVIDER: S-EPMC5333811 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

Colon cancer modulation by a diabetic environment: A single institutional experience.

Prieto Isabel I Del Puerto-Nevado Laura L Gonzalez Nieves N Portal-Nuñez Sergio S Zazo Sandra S Corton Marta M Minguez Pablo P Gomez-Guerrero Carmen C Arce Jose Miguel JM Sanz Ana Belen AB Mas Sebastian S Aguilera Oscar O Alvarez-Llamas Gloria G Esbrit Pedro P Ortiz Alberto A Ayuso Carmen C Egido Jesus J Rojo Federico F Garcia-Foncillas Jesus J

PloS one 20170302 3

<h4>Background</h4>Multiple observational studies suggest an increased risk of colon cancer in patients with diabetes mellitus (DM). This can theoretically be the result of an influence of the diabetic environment on carcinogenesis or the tumor biologic behavior.<h4>Aim</h4>To gain insight into the influence of a diabetic environment on colon cancer characteristics and outcomes.<h4>Material and methods</h4>Retrospective analysis of clinical records in an academic tertiary care hospital with deta ...[more]

PMID: 28253286

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Project description:Background: Laparoscopy is rapidly replacing laparotomy in the field of gynecologic surgery. Generally, there are limited data concerning the utility of single-incision laparoscopic surgery (SILS) in gynecologic surgery. Specifically, in Saudi Arabia, a third-world country, data are further limited; only one related study has been conducted so far. The purpose of this study is to retrospectively report our single-institutional experience of SILS in terms of feasibility, safety and perioperative outcomes in the management of various gynecologic conditions. Methods: The study took place at the Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia. From January 2012 to May 2016, all gynecologic patients who underwent SILS procedures were analyzed for pre-, intra- and post-operative details. SILS was performed using a single multi-port trocar and standard laparoscopic instruments. Results: A total of 54 patients underwent 66 SILS procedures. The median age and body mass index (BMI) were 36 years and 28.2 kg/m 2, respectively. Fourteen patients (26%) had ? 1 previous abdominal and/or pelvic surgeries. Twenty-four patients (44.4%) were nulliparous. The three most commonly performed SILS procedures were unilateral salpingo-oophorectomy (45.5%) and unilateral ovarian cystectomy (27.3%) and adhesiolysis (6.1%). The median operative time, estimated blood loss and hospital stay were 74 min, 50 ml and 1 day, respectively. Three patients required conversion to laparotomy, as follows: unidentified non-stopping bleeding source (n=1) and endometriosis stage IV resulting in difficult dissection (n=2). One patient developed post-operative incisional hernia that was treated surgically. The median patients' post-operative pain (according to Wong-Baker FACES Foundation pain rating scale) within 4 hours was 2. At 4-week post-operatively, the median wound scar length (measured at outpatient clinic) was 2 cm. Conclusions: SILS is feasible, safe and associated with acceptable clinical and surgical outcomes.

Dataset Information

Colon cancer modulation by a diabetic environment: A single institutional experience.

Background

Aim

Material and methods

Results

Conclusion

Publications

Colon cancer modulation by a diabetic environment: A single institutional experience.

Similar Datasets

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