Ontology highlight
ABSTRACT:
SUBMITTER: Offenbacher AR
PROVIDER: S-EPMC5333924 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Offenbacher Adam R AR Zhu Hui H Klinman Judith P JP
Tetrahedron letters 20160822 41
Soybean lipoxygenase-1 (SLO-1) catalyzes the C-H abstraction from the reactive carbon (C-11) in linoleic acid as the first and rate-determining step in the formation of alkylhydroperoxides. While previous labeling strategies have focused on deuterium labeling to ascertain the primary and secondary kinetic isotope effects for this reaction, there is an emerging interest and need for selectively enriched <sup>13</sup>C isotopologues. In this report, we present synthetic strategies for site-specifi ...[more]