Dataset Information

SBRT for early-stage glottic larynx cancer-Initial clinical outcomes from a phase I clinical trial.

ABSTRACT:

Purpose

To confirm safety and feasibility of hypofractionated SBRT for early-stage glottic laryngeal cancer.

Methods

Twenty consecutive patients with cTis-T2N0M0 carcinoma of glottic larynx were enrolled. Patients entered dose-fractionation cohorts of incrementally shorter bio-equivalent schedules starting with 50 Gy in 15 fractions (fx), followed by 45 Gy/10 fx and, finally, 42.5 Gy/5 fx. Maximum combined CTV-PTV expansion was limited to 5 mm. Patients were treated on a Model G5 Cyberknife (Accuray, Sunnyvale, CA).

Results

Median follow-up is 13.4 months (range: 5.6-24.6 months), with 12 patients followed for at least one year. Maximum acute toxicity consisted of grade 2 hoarseness and dysphagia. Maximum chronic toxicity was seen in one patient treated with 45 Gy/10 fx who continued to smoke >1 pack/day and ultimately required protective tracheostomy. At 1-year follow-up, estimated local disease free survival for the full cohort was 82%. Overall survival is 100% at last follow-up.

Conclusions

We were able to reduce equipotent total fractions of SBRT from 15 to 5 without exceeding protocol-defined acute/subacute toxicity limits. With limited follow-up, disease control appears comparable to standard treatment. We continue to enroll to the 42.5 Gy/5 fx cohort and follow patients for late toxicity.

Trial registration

ClinicalTrials.gov NCT01984502.

SUBMITTER: Schwartz DL

PROVIDER: S-EPMC5333979 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

SBRT for early-stage glottic larynx cancer-Initial clinical outcomes from a phase I clinical trial.

Schwartz David L DL Sosa Alan A Chun Stephen G SG Ding Chiuxiong C Xie Xian-Jin XJ Nedzi Lucien A LA Timmerman Robert D RD Sumer Baran D BD

PloS one 20170302 3

<h4>Purpose</h4>To confirm safety and feasibility of hypofractionated SBRT for early-stage glottic laryngeal cancer.<h4>Methods</h4>Twenty consecutive patients with cTis-T2N0M0 carcinoma of glottic larynx were enrolled. Patients entered dose-fractionation cohorts of incrementally shorter bio-equivalent schedules starting with 50 Gy in 15 fractions (fx), followed by 45 Gy/10 fx and, finally, 42.5 Gy/5 fx. Maximum combined CTV-PTV expansion was limited to 5 mm. Patients were treated on a Model G5 ...[more]

PMID: 28253270

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Dataset Information

SBRT for early-stage glottic larynx cancer-Initial clinical outcomes from a phase I clinical trial.

Purpose

Methods

Results

Conclusions

Trial registration

Publications

SBRT for early-stage glottic larynx cancer-Initial clinical outcomes from a phase I clinical trial.

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