Ontology highlight
ABSTRACT:
SUBMITTER: Delabaere L
PROVIDER: S-EPMC5334535 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Delabaere Laetitia L Ertl Henry A HA Massey Dashiell J DJ Hofley Carolyn M CM Sohail Faraz F Bienenstock Elisa J EJ Sebastian Hans H Chiolo Irene I LaRocque Jeannine R JR
Aging cell 20161221 2
Aging is characterized by genome instability, which contributes to cancer formation and cell lethality leading to organismal decline. The high levels of DNA double-strand breaks (DSBs) observed in old cells and premature aging syndromes are likely a primary source of genome instability, but the underlying cause of their formation is still unclear. DSBs might result from higher levels of damage or repair defects emerging with advancing age, but repair pathways in old organisms are still poorly un ...[more]