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Higher-order power harmonics of pulsed electrical stimulation modulates corticospinal contribution of peripheral nerve stimulation.


ABSTRACT: It is well established that electrical-stimulation frequency is crucial to determining the scale of induced neuromodulation, particularly when attempting to modulate corticospinal excitability. However, the modulatory effects of stimulation frequency are not only determined by its absolute value but also by other parameters such as power at harmonics. The stimulus pulse shape further influences parameters such as excitation threshold and fiber selectivity. The explicit role of the power in these harmonics in determining the outcome of stimulation has not previously been analyzed. In this study, we adopted an animal model of peripheral electrical stimulation that includes an amplitude-adapted pulse train which induces force enhancements with a corticospinal contribution. We report that the electrical-stimulation-induced force enhancements were correlated with the amplitude of stimulation power harmonics during the amplitude-adapted pulse train. In an exploratory analysis, different levels of correlation were observed between force enhancement and power harmonics of 20-80?Hz (r?=?0.4247, p?=?0.0243), 100-180?Hz (r?=?0.5894, p?=?0.0001), 200-280?Hz (r?=?0.7002, p?

SUBMITTER: Chen CF 

PROVIDER: S-EPMC5335254 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Higher-order power harmonics of pulsed electrical stimulation modulates corticospinal contribution of peripheral nerve stimulation.

Chen Chiun-Fan CF   Bikson Marom M   Chou Li-Wei LW   Shan Chunlei C   Khadka Niranjan N   Chen Wen-Shiang WS   Fregni Felipe F  

Scientific reports 20170303


It is well established that electrical-stimulation frequency is crucial to determining the scale of induced neuromodulation, particularly when attempting to modulate corticospinal excitability. However, the modulatory effects of stimulation frequency are not only determined by its absolute value but also by other parameters such as power at harmonics. The stimulus pulse shape further influences parameters such as excitation threshold and fiber selectivity. The explicit role of the power in these  ...[more]

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2023-05-01 | GSE220261 | GEO