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Circulating TNF Receptors 1 and 2 Predict Mortality in Patients with End-stage Renal Disease Undergoing Dialysis.


ABSTRACT: Relatively high circulating levels of soluble tumor necrosis factor (TNF) receptors (TNFRs: TNFR1, TNFR2) have been associated with not only progression to end-stage renal disease but also mortality in patients with diabetes. It remains unknown whether elevated TNFR levels in haemodialysis patients are associated with mortality. We studied 319 patients receiving maintenance haemodialysis who were followed for a median of 53 months. Circulating markers of TNF pathway (TNF? and TNFRs) were measured with immunoassay. Strong positive correlations between TNFR1 and TNFR2 were observed (r?=?0.81, P?

SUBMITTER: Gohda T 

PROVIDER: S-EPMC5335256 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Circulating TNF Receptors 1 and 2 Predict Mortality in Patients with End-stage Renal Disease Undergoing Dialysis.

Gohda Tomohito T   Maruyama Shuntaro S   Kamei Nozomu N   Yamaguchi Saori S   Shibata Terumi T   Murakoshi Maki M   Horikoshi Satoshi S   Tomino Yasuhiko Y   Ohsawa Isao I   Gotoh Hiromichi H   Nojiri Shuko S   Suzuki Yusuke Y  

Scientific reports 20170303


Relatively high circulating levels of soluble tumor necrosis factor (TNF) receptors (TNFRs: TNFR1, TNFR2) have been associated with not only progression to end-stage renal disease but also mortality in patients with diabetes. It remains unknown whether elevated TNFR levels in haemodialysis patients are associated with mortality. We studied 319 patients receiving maintenance haemodialysis who were followed for a median of 53 months. Circulating markers of TNF pathway (TNFα and TNFRs) were measure  ...[more]

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