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Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly.


ABSTRACT: This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over. Psychological distress was assessed using the University of California at Los Angeles Loneliness Scale (UCLA-LS) and Geriatric Depression Scale (GDS) Short-Form. Cognitive function was evaluated using the MMSE and MoCA. White matter hyperintensities (WMH) were assessed using magnetic resonance imaging. After 5.2-year follow-up, the reductions in MMSE and MoCA scores and the increases in periventricular (P)WMH, deep (D)WMH, and total WMH volumes in the empty-nest elderly were greater than those in the non-empty-nest elderly (P?

SUBMITTER: Duan D 

PROVIDER: S-EPMC5335556 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly.

Duan Dandan D   Dong Yuanli Y   Zhang Hua H   Zhao Yingxin Y   Diao Yutao Y   Cui Yi Y   Wang Juan J   Chai Qiang Q   Liu Zhendong Z  

Scientific reports 20170303


This study evaluated the association between empty-nest-related psychological distress and the progression of white matter lesions (WMLs) and cognitive impairment in 219 elderly subjects aged 60 years or over. Psychological distress was assessed using the University of California at Los Angeles Loneliness Scale (UCLA-LS) and Geriatric Depression Scale (GDS) Short-Form. Cognitive function was evaluated using the MMSE and MoCA. White matter hyperintensities (WMH) were assessed using magnetic reson  ...[more]

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