Ontology highlight
ABSTRACT:
SUBMITTER: Hicks DF
PROVIDER: S-EPMC5335661 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Hicks Daniel F DF Goossens Nicolas N Blas-García Ana A Tsuchida Takuma T Wooden Benjamin B Wallace Michael C MC Nieto Natalia N Lade Abigale A Redhead Benjamin B Cederbaum Arthur I AI Dudley Joel T JT Fuchs Bryan C BC Lee Youngmin A YA Hoshida Yujin Y Friedman Scott L SL
Scientific reports 20170303
We have used a computational approach to identify anti-fibrotic therapies by querying a transcriptome. A transcriptome signature of activated hepatic stellate cells (HSCs), the primary collagen-secreting cell in liver, and queried against a transcriptomic database that quantifies changes in gene expression in response to 1,309 FDA-approved drugs and bioactives (CMap). The flavonoid apigenin was among 9 top-ranked compounds predicted to have anti-fibrotic activity; indeed, apigenin dose-dependent ...[more]