Ontology highlight
ABSTRACT:
SUBMITTER: Hillyer P
PROVIDER: S-EPMC5337151 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Hillyer Philippa P Mane Viraj P VP Chen Aaron A Dos Santos Maria B MB Schramm Lynnsie M LM Shepard Rachel E RE Luongo Cindy C Le Nouën Cyril C Huang Lei L Yan Lihan L Buchholz Ursula J UJ Jubin Ronald G RG Collins Peter L PL Rabin Ronald L RL
Virology 20170131
Whether respiratory syncytial virus (RSV) induces severe infantile pulmonary disease may depend on viral strain and expression of types I and III interferons (IFNs). These IFNs impact disease severity by inducing expression of many anti-viral IFN-stimulated genes (ISGs). To investigate the impact of RSV strain on IFN and ISG expression, we stimulated human monocyte-derived DCs (MDDCs) with either RSV A2 or Line 19 and measured expression of types I and III IFNs and ISGs. At 24h, A2 elicited high ...[more]