Ontology highlight
ABSTRACT:
SUBMITTER: Kotini AG
PROVIDER: S-EPMC5337161 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Kotini Andriana G AG Chang Chan-Jung CJ Chow Arthur A Yuan Han H Ho Tzu-Chieh TC Wang Tiansu T Vora Shailee S Solovyov Alexander A Husser Chrystel C Olszewska Malgorzata M Teruya-Feldstein Julie J Perumal Deepak D Klimek Virginia M VM Spyridonidis Alexandros A Rampal Raajit K RK Silverman Lewis L Reddy E Premkumar EP Papaemmanuil Elli E Parekh Samir S Greenbaum Benjamin D BD Leslie Christina S CS Kharas Michael G MG Papapetrou Eirini P EP
Cell stem cell 20170216 3
Myeloid malignancy is increasingly viewed as a disease spectrum, comprising hematopoietic disorders that extend across a phenotypic continuum ranging from clonal hematopoiesis to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this study, we derived a collection of induced pluripotent stem cell (iPSC) lines capturing a range of disease stages encompassing preleukemia, low-risk MDS, high-risk MDS, and secondary AML. Upon their differentiation, we found hematopoietic phenotypes ...[more]