Ontology highlight
ABSTRACT:
SUBMITTER: Borensztein M
PROVIDER: S-EPMC5337400 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20170130 3
The long noncoding RNA Xist is expressed from only the paternal X chromosome in mouse preimplantation female embryos and mediates transcriptional silencing of that chromosome. In females, absence of Xist leads to postimplantation lethality. Here, through single-cell RNA sequencing of early preimplantation mouse embryos, we found that the initiation of imprinted X-chromosome inactivation absolutely requires Xist. Lack of paternal Xist leads to genome-wide transcriptional misregulation in the earl ...[more]