Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.
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ABSTRACT:
SUBMITTER: Lee YH
PROVIDER: S-EPMC5337429 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension.
Lee Yu Ho YH Kim Yang Gyun YG Moon Ju-Young JY Kim Jin Sug JS Jeong Kyung-Hwan KH Lee Tae Won TW Ihm Chun-Gyoo CG Lee Sang Ho SH
Electrolyte & blood pressure : E & BP 20161231 2
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of <i>TH</i> could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension ...[more]
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