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Prospective evaluation of luteal phase length and natural fertility.

ABSTRACT: To evaluate the impact of a short luteal phase on fecundity.Prospective time-to-pregnancy cohort study.Not applicable.Women trying to conceive, ages 30-44 years, without known infertility.Daily diaries, ovulation prediction testing, standardized pregnancy testing.Subsequent cycle fecundity.Included in the analysis were 1,635 cycles from 284 women. A short luteal phase (?11 days including the day of ovulation) occurred in 18% of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy in the subsequent cycle immediately following the short luteal phase compared with women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months there was no significant difference in cumulative probability of pregnancy.Although an isolated cycle with a short luteal phase may negatively affect short-term fertility, incidence of infertility at 12 months was not significantly higher among these women.NCT01028365.

SUBMITTER: Crawford NM

PROVIDER: S-EPMC5337433 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Prospective evaluation of luteal phase length and natural fertility.

Crawford Natalie M NM Pritchard David A DA Herring Amy H AH Steiner Anne Z AZ

Fertility and sterility 20170105 3

<h4>Objective</h4>To evaluate the impact of a short luteal phase on fecundity.<h4>Design</h4>Prospective time-to-pregnancy cohort study.<h4>Setting</h4>Not applicable.<h4>Patient(s)</h4>Women trying to conceive, ages 30-44 years, without known infertility.<h4>Intervention(s)</h4>Daily diaries, ovulation prediction testing, standardized pregnancy testing.<h4>Main outcome measure(s)</h4>Subsequent cycle fecundity.<h4>Result(s)</h4>Included in the analysis were 1,635 cycles from 284 women. A short ...[more]

PMID: 28065408

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Project description:UnlabelledTo compare Crinone vaginal progesterone gel with intramuscularly injected progesterone for luteal phase support in progesterone-supplemented frozen-thawed embryo transfer (FET) cycles, a randomized prospective study of patients qualified for FET was conducted between September 2010 and January 2013 at a hospital in Shanghai, China. From the day of transformation into secretory phase endometrium (day 0), Crinone vaginal gel (90 mg/d) was administered to patients in the Gel Group, while progesterone (40 mg/d) was injected intramuscularly in patients in the Inj Group (n = 750 per group). All patients received oral dydrogesterone (20 mg/d) and estradiol valerate (4–8 mg/d). Day 3 embryos with the highest pre-frozen scores were transferred to patients in the two groups and the clinical outcomes compared. This study comprised 1,500 cycles (750 in each group). Twenty-nine cycles in the Gel Group and 24 in the Inj Group were withdrawn. There were no significant differences between groups in age, endometrial thickness, endometrial preparation time or number of embryos transferred. No significant differences were observed between the Gel Group and Inj Group in the rates of live birth (32.6% vs. 31.7%, P = 0.71), clinical pregnancy (40.1% vs. 40.6%, P = 0.831), implantation (25.8% vs. 25.3%, P = 0.772), abortion (16.3% vs. 18.3%, P = 0.514) or ectopic pregnancy (2.8% vs. 4.4%, P = 0.288). Multivariate logistic regression analysis revealed that the odds ratios (95% confidence intervals) for the rates of live birth, clinical pregnancy, abortion and ectopic pregnancy (Gel Group relative to Inj Group) were 1.036 (0.829–1.295), 0.971 (0.785–1.200), 0.919 (0.595–1.420) and 0.649 (0.261–1.614), respectively. Our study revealed that using Crinone vaginal gel in FET cycles achieved similar pregnancy outcomes to intramuscular progesterone, indicating that vaginal gel is a viable alternative to intramuscular injection.Trial registrationChinese Clinical Trial Registry ChiCTR-TRC-14004565.

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Prospective evaluation of luteal phase length and natural fertility.

Publications

Prospective evaluation of luteal phase length and natural fertility.

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