Ontology highlight
ABSTRACT:
SUBMITTER: Lin HH
PROVIDER: S-EPMC5337949 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Lin Han-Huei HH Gutenberg Angelika A Chen Tzu-Yu TY Tsai Nu-Man NM Lee Chia-Jung CJ Cheng Yu-Che YC Cheng Wen-Hui WH Tzou Ywh-Min YM Caturegli Patrizio P Tzou Shey-Cherng SC
Scientific reports 20170306
Autoimmune hypophysitis (AH) is a chronic inflammatory disease characterized by infiltration of T and B lymphocytes in the pituitary gland. The mechanisms through which infiltrating lymphocytes cause disease remain unknown. Using a mouse model of AH we assessed whether T lymphocytes undergo activation in the pituitary gland. Infiltrating T cells co-localized with dendritic cells in the pituitary and produced increased levels of interferon-γ and interleukin-17 upon stimulation in vitro. Assessing ...[more]