Ontology highlight
ABSTRACT:
SUBMITTER: Han D
PROVIDER: S-EPMC5337984 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Scientific reports 20170306
CCCTC-binding factor (CTCF) plays an essential role in regulating the structure of chromatin by binding DNA strands for defining the boundary between active and heterochromatic DNA. However, the role of CTCF in DNA damage response remains elusive. Here, we show that CTCF is quickly recruited to the sites of DNA damage. The fast recruitment is mediated by the zinc finger domain and poly (ADP-ribose) (PAR). Further analyses show that only three zinc finger motifs are essential for PAR recognition. ...[more]