Genetics of vascular dementia - review from the ICVD working group.

ABSTRACT:

Background

Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms could improve our understanding of vascular dementia, leading to a potential translation of this knowledge to clinical practice.

Discussion

In this review, we discuss what is currently known about the genetics of vascular dementia. The identification of causal genes remains limited to monogenic forms of the disease, with findings for sporadic vascular dementia being less robust. However, progress in genetic research on associated phenotypes, such as cerebral small vessel disease, Alzheimer's disease, and stroke, have the potential to inform on the genetics of va

SUBMITTER: Ikram MA 

PROVIDER: S-EPMC5338082 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature