Ontology highlight
ABSTRACT:
SUBMITTER: Weinberger A
PROVIDER: S-EPMC5338251 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Weinberger Andreas A Walter Vivien V MacEwan Sarah R SR Schmatko Tatiana T Muller Pierre P Schroder André P AP Chilkoti Ashutosh A Marques Carlos M CM
Scientific reports 20170306
Although cationic cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting cell internalization by active pathways, attachment of cargo molecules to CPPs invariably reduces their cellular uptake. We show here that CPP binding to lipid bilayers, a simple model of the cell membrane, can be recovered by designing cargo molecules that self-assemble into spherical micelles and increase the local interfacial density of CPP on the surface of the cargo. Experiments performed o ...[more]