Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC5338345 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Guo Chun C Wilkinson Kevin A KA Evans Ashley J AJ Rubin Philip P PP Henley Jeremy M JM
Scientific reports 20170306
The GTPase dynamin-related protein 1 (Drp1) is essential for physiological and pathophysiological mitochondrial fission. DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell death during reperfusion after ischaemia by enhancing Drp1 partitioning to the mitochondrial outer membrane (MOM), which causes cytochrome c release and apoptosis. However, how deSUMOylation recruits Drp1 to the MOM is unknown. Here we show that deSUMOylation selectively promotes Drp1 binding to the MOM resident adaptor p ...[more]