Ontology highlight
ABSTRACT:
SUBMITTER: Richard AS
PROVIDER: S-EPMC5338370 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Richard Audrey Stéphanie AS Shim Byoung-Shik BS Kwon Young-Chan YC Zhang Rong R Otsuka Yuka Y Schmitt Kimberly K Berri Fatma F Diamond Michael S MS Choe Hyeryun H
Proceedings of the National Academy of Sciences of the United States of America 20170206 8
Although a causal relationship between Zika virus (ZIKV) and microcephaly has been established, it remains unclear why ZIKV, but not other pathogenic flaviviruses, causes congenital defects. Here we show that when viruses are produced in mammalian cells, ZIKV, but not the closely related dengue virus (DENV) or West Nile virus (WNV), can efficiently infect key placental barrier cells that directly contact the fetal bloodstream. We show that AXL, a receptor tyrosine kinase, is the primary ZIKV ent ...[more]