Contribution of epigenetic mechanisms to variation in cancer risk among tissues.
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ABSTRACT:
SUBMITTER: Klutstein M
PROVIDER: S-EPMC5338490 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
Contribution of epigenetic mechanisms to variation in cancer risk among tissues.
Klutstein Michael M Moss Joshua J Kaplan Tommy T Cedar Howard H
Proceedings of the National Academy of Sciences of the United States of America 20170213 9
Recently, it was suggested that tissue variation in cancer risk originates from differences in the number of stem-cell divisions underlying each tissue, leading to different mutation loads. We show that this variation is also correlated with the degree of aberrant CpG island DNA methylation in normal cells. Methylation accumulates during aging in a subset of molecules, suggesting that the epigenetic landscape within a founder-cell population may contribute to tumor formation. ...[more]
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