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Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution.

ABSTRACT: Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T₁ of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ?3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d₆ or methanol-d₄). The approximate values of the HP decay time for propane dissolved in acetone-d₆ are 35.1 and 28.6 s for the CH₂ group and the CH₃ group, respectively (similar values were obtained for propane dissolved in methanol-d₄), which are ?50 times larger than the gaseous propane T₁ value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.

SUBMITTER: Burueva DB

PROVIDER: S-EPMC5338591 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution.

Burueva Dudari B DB Romanov Alexey S AS Salnikov Oleg G OG Zhivonitko Vladimir V VV Chen Yu-Wen YW Barskiy Danila A DA Chekmenev Eduard Y EY Hwang Dennis W DW Kovtunov Kirill V KV Koptyug Igor V IV

The journal of physical chemistry. C, Nanomaterials and interfaces 20170207 8

Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time <i>T</i><sub>1</sub> of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state ...[more]

PMID: 28286597

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Project description:We report a systematic study of relaxation dynamics of hyperpolarized (HP) propane and HP propane-d6 prepared by heterogeneous pairwise parahydrogen addition to propylene and propylene-d6 respectively. Long-lived spin states (LLS) created for these molecules at the low magnetic field of 0.0475 T were employed for this study. The parahydrogen-induced overpopulation of a HP propane LLS decays exponentially with time constant (TLLS) approximately 3-fold greater than the corresponding T1 values. Both TLLS and T1 increase linearly with propane pressure in the range from 1 atm (the most biomedically relevant conditions for pulmonary MRI) to 5 atm. The TLLS value of HP propane gas at 1 atm is ~3 s. Deuteration of the substrate (propylene-d6) yields hyperpolarized propane-d6 gas with TLLS values approximately 20% shorter than those of hyperpolarized fully protonated propane gas, indicating that deuteration does not benefit the lifetime of the LLS HP state. The use of pH2 or Xe/N2 buffering gas during heterogeneous hydrogenation reaction (leading to production of 100% HP propane (no buffering gas) versus 43% HP propane gas (with 57% buffering gas) composition mixtures) results in (i) no significant changes in T1, (ii) decrease of TLLS values (by 35±7% and 8±7% respectively); and (iii) an increase of the polarization levels of HP propane gas with a propane concentration decrease (by 1.6±0.1-fold and 1.4±0.1-fold respectively despite the decrease in TLLS, which leads to disproportionately greater polarization losses during HP gas transport). Moreover, we demonstrate the feasibility of HP propane cryo-collection (which can be potentially useful for preparing larger amounts of concentrated HP propane, when buffering gas is employed), and TLLS of liquefied HP propane reaches 14.7 seconds, which is greater than the TLLS value of HP propane gas at any pressure studied. Finally, we have explored the utility of using a partial Spin-Lock Induced Crossing (SLIC) radio frequency (RF) pulse sequence for converting the overpopulated LLS into observable 1H nuclear magnetization at low magnetic field. We find that (i) the bulk of the overpopulated LLS is retained even when the optimal or near-optimal values of SLIC pulse duration are employed, and (ii) the overpopulated LLS of propane is also relatively immune to strong RF pulses-thereby, indicating that LLS is highly suitable as a spin-polarization reservoir in the context of NMR/MRI detection applications. The presented findings may be useful for improving the levels of polarization of HP propane produced by HET-PHIP via the use of an inert buffer gas; increasing the lifetime of the HP state during preparation and storage; and developing efficient approaches for ultrafast MR imaging of HP propane in the context of biomedical applications of HP propane gas, including its potential use as an inhalable contrast agent.

Dataset Information

Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution.

Publications

Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution.

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