Ontology highlight
ABSTRACT:
SUBMITTER: Rau CD
PROVIDER: S-EPMC5338604 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Rau Christoph D CD Romay Milagros C MC Tuteryan Mary M Wang Jessica J-C JJ Santolini Marc M Ren Shuxun S Karma Alain A Weiss James N JN Wang Yibin Y Lusis Aldons J AJ
Cell systems 20161117 1
We previously reported a genetic analysis of heart failure traits in a population of inbred mouse strains treated with isoproterenol to mimic catecholamine-driven cardiac hypertrophy. Here, we apply a co-expression network algorithm, wMICA, to perform a systems-level analysis of left ventricular transcriptomes from these mice. We describe the features of the overall network but focus on a module identified in treated hearts that is strongly related to cardiac hypertrophy and pathological remodel ...[more]