Unknown

Dataset Information

0

Prediction and classification of Alzheimer disease based on quantification of MRI deformation.


ABSTRACT: Detecting early morphological changes in the brain and making early diagnosis are important for Alzheimer's disease (AD). High resolution magnetic resonance imaging can be used to help diagnosis and prediction of the disease. In this paper, we proposed a machine learning method to discriminate patients with AD or mild cognitive impairment (MCI) from healthy elderly and to predict the AD conversion in MCI patients by computing and analyzing the regional morphological differences of brain between groups. Distance between each pair of subjects was quantified from a symmetric diffeomorphic registration, followed by an embedding algorithm and a learning approach for classification. The proposed method obtained accuracy of 96.5% in differentiating mild AD from healthy elderly with the whole-brain gray matter or temporal lobe as region of interest (ROI), 91.74% in differentiating progressive MCI from healthy elderly and 88.99% in classifying progressive MCI versus stable MCI with amygdala or hippocampus as ROI. This deformation-based method has made full use of the pair-wise macroscopic shape difference between groups and consequently increased the power for discrimination.

SUBMITTER: Long X 

PROVIDER: S-EPMC5338815 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prediction and classification of Alzheimer disease based on quantification of MRI deformation.

Long Xiaojing X   Chen Lifang L   Jiang Chunxiang C   Zhang Lijuan L  

PloS one 20170306 3


Detecting early morphological changes in the brain and making early diagnosis are important for Alzheimer's disease (AD). High resolution magnetic resonance imaging can be used to help diagnosis and prediction of the disease. In this paper, we proposed a machine learning method to discriminate patients with AD or mild cognitive impairment (MCI) from healthy elderly and to predict the AD conversion in MCI patients by computing and analyzing the regional morphological differences of brain between  ...[more]

Similar Datasets

| S-EPMC10310810 | biostudies-literature
| S-EPMC11349618 | biostudies-literature
2009-01-12 | GSE4229 | GEO
| S-EPMC3815961 | biostudies-literature
| S-EPMC8466762 | biostudies-literature
| S-EPMC8689441 | biostudies-literature
| S-EPMC2938772 | biostudies-literature
| S-EPMC5288688 | biostudies-literature
| S-EPMC7964474 | biostudies-literature
| S-EPMC7303669 | biostudies-literature