Ontology highlight
ABSTRACT:
SUBMITTER: De Felice F
PROVIDER: S-EPMC5338854 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
De Felice Francesca F Tombolini Vincenzo V Marampon Francesco F Musella Angela A Marchetti Claudia C
Drug design, development and therapy 20170301
The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition and aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP) proteins play a key role in DNA repair mechanisms and represent a valid target for new ...[more]