Ontology highlight
ABSTRACT:
SUBMITTER: Nassal DM
PROVIDER: S-EPMC5338919 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nassal Drew M DM Wan Xiaoping X Liu Haiyan H Maleski Danielle D Ramirez-Navarro Angelina A Moravec Christine S CS Ficker Eckhard E Laurita Kenneth R KR Deschênes Isabelle I
eLife 20170306
Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous cardiac pathologies. However, it remains unknown if KChIP2 loss is merely a symptom or involved in disease development. Using rat and human derived cardiomyocytes, we identify a previously unobserved transcriptional capacity for cardiac KChIP2 critical ...[more]