Ontology highlight
ABSTRACT:
SUBMITTER: Mehandru S
PROVIDER: S-EPMC533925 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Mehandru Saurabh S Wrin Terri T Galovich Justin J Stiegler Gabriela G Vcelar Brigitta B Hurley Arlene A Hogan Christine C Vasan Sandhya S Katinger Hermann H Petropoulos Christos J CJ Markowitz Martin M
Journal of virology 20041201 24
As the AIDS epidemic continues unabated, the development of a human immunodeficiency virus (HIV) vaccine is critical. Ideally, an effective vaccine should elicit cell-mediated and neutralizing humoral immune responses. We have determined the in vitro susceptibility profile of sexually transmitted viruses from 91 patients with acute and early HIV-1 infection to three monoclonal antibodies, 2G12, 2F5, and 4E10. Using a recombinant virus assay to measure neutralization, we found all transmitted vir ...[more]