Ontology highlight
ABSTRACT:
SUBMITTER: Mancuso N
PROVIDER: S-EPMC5339290 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Mancuso Nicholas N Shi Huwenbo H Goddard Pagé P Kichaev Gleb G Gusev Alexander A Pasaniuc Bogdan B
American journal of human genetics 20170223 3
Although genome-wide association studies (GWASs) have identified thousands of risk loci for many complex traits and diseases, the causal variants and genes at these loci remain largely unknown. Here, we introduce a method for estimating the local genetic correlation between gene expression and a complex trait and utilize it to estimate the genetic correlation due to predicted expression between pairs of traits. We integrated gene expression measurements from 45 expression panels with summary GWA ...[more]