Ontology highlight
ABSTRACT:
SUBMITTER: O'Connor DH
PROVIDER: S-EPMC533930 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
O'Connor David H DH McDermott Adrian B AB Krebs Kendall C KC Dodds Elizabeth J EJ Miller Jacqueline E JE Gonzalez Edna J EJ Jacoby Timothy J TJ Yant Levi L Piontkivska Helen H Pantophlet Ralph R Burton Dennis R DR Rehrauer William M WM Wilson Nancy N Hughes Austin L AL Watkins David I DI
Journal of virology 20041201 24
CD8(+) T lymphocytes (CD8-TL) select viral escape variants in both human immunodeficiency virus and simian immunodeficiency virus (SIV) infections. The frequency of CD8-TL viral escape as well as the contribution of escape to overall virus diversification has not been assessed. We quantified CD8-TL selection in SIV infections by sequencing viral genomes from 35 SIVmac239-infected animals at the time of euthanasia. Here we show that positive selection for sequences encoding 46 known CD8-TL epitop ...[more]