Ontology highlight
ABSTRACT:
SUBMITTER: Hsu EJ
PROVIDER: S-EPMC5339511 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
The Journal of general physiology 20170223 3
Functional eukaryotic voltage-gated Na<sup>+</sup> (Na<sub>V</sub>) channels comprise four domains (DI-DIV), each containing six membrane-spanning segments (S1-S6). Voltage sensing is accomplished by the first four membrane-spanning segments (S1-S4), which together form a voltage-sensing domain (VSD). A critical Na<sub>V</sub> channel gating process, inactivation, has previously been linked to activation of the VSDs in DIII and DIV. Here, we probe this interaction by using voltage-clamp fluorome ...[more]