Ontology highlight
ABSTRACT:
SUBMITTER: Ercan E
PROVIDER: S-EPMC5339668 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Ercan Ebru E Han Juliette M JM Di Nardo Alessia A Winden Kellen K Han Min-Joon MJ Hoyo Leonie L Saffari Afshin A Leask Andrew A Geschwind Daniel H DH Sahin Mustafa M
The Journal of experimental medicine 20170209 3
Disruption of myelination during development has been implicated in a range of neurodevelopmental disorders including tuberous sclerosis complex (TSC). TSC patients with autism display impairments in white matter integrity. Similarly, mice lacking neuronal <i>Tsc1</i> have a hypomyelination phenotype. However, the mechanisms that underlie these phenotypes remain unknown. In this study, we demonstrate that neuronal TSC1/2 orchestrates a program of oligodendrocyte maturation through the regulated ...[more]