Ontology highlight
ABSTRACT:
SUBMITTER: Laidlaw BJ
PROVIDER: S-EPMC5339677 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Laidlaw Brian J BJ Schmidt Timothy H TH Green Jesse A JA Allen Christopher D C CD Okada Takaharu T Cyster Jason G JG
The Journal of experimental medicine 20170131 3
Identification of germinal center (GC) B cells is typically reliant on the use of surface activation markers that exhibit a wide range of expression. Here, we identify Ephrin-B1, a ligand for Eph-related receptor tyrosine kinases, as a specific marker of mature GC B cells. The number of Ephrin-B1<sup>+</sup> GC B cells increases during the course of an immune response with Ephrin-B1<sup>+</sup> GC B cells displaying elevated levels of Bcl6, <i>S1pr2</i>, and <i>Aicda</i> relative to their Ephrin ...[more]